Benzylamine → HCID 54474668、化合物

反応式

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=2)[C:17](O)=[O:18])[CH:10]([O:23][CH2:24][C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:26]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:35]([NH2:42])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH2:35]([NH:42][C:17]([C:16]1[CH:15]=[C:14]([CH:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9][CH:10]2[O:23][CH2:24][C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:26]=2)[CH:22]=[CH:21][CH:20]=1)=[O:18])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

参加物

反応物 2

HCID 7504Benzylamine

HCID 22128904HCID 22128904、化合物

生成物 1

HCID 54474668HCID 54474668、化合物

実験手順

In an analogous manner to that described in Example 36(b), by condensing (3RS,4RS)-3-(1 -tert-butoxycarbonyl-3-naphthalen-2-ylmethoxy-piperidin-4-yl)-benzoic acid with benzylamine using 1,1-carbonyidiimidazole as the condensation agent there was obtained tert-butyl (3RS,4RS)-4-(3-benzylcarbamoyl-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate as a colourless oil; MS: 551 (M+H)+.

出典と根拠

ORDレコード: ord-b497c4c692104a0896236656deb769c6
出典データセット: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06051712

反応ノート

読み込み中…

参加物