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Ethyl Acetate → HCID 11011182、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 反応物 | 2-Hydroxy-4-methyl-3-nitropyridine | HCID 345370 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 11011182 | HCID 11011182 | 56% |
反応手順
To a stirred suspension of 4-methyl-3-nitro-2-pyridone (2.0 g, 13 mmol) in DMF (60 mL) was added NaH (60% suspension in oil, 0.52 g). After 1 hour, 4-methoxybenzyl chloride (1.8 mL) was added, and the mixture was stirred at rt overnight. Ethyl acetate was added, and the organic phase was washed with water, dried, filtered and evaporated. Chromatography of the residue over silica gel (ethyl acetate/hexane) gave 1-(4-methoxybenzyl)-4-methyl-3-nitro-2-pyridone (2.0 g, 7.3 mmol, 56%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06054470 |
| 出典データセット | uspto-grants-2000_04 |
| ORD ID | ord-6fe0c71066cb46978ebd0d24c3978065 |
| 出典メモ | uspto-grants-2000_04 |