1-Methoxycyclohexene → 5-(3,5-Dimethylphenylthio)-4-isopropyl-1-[2-(1-methoxycyclohexyloxy)ethoxymethyl)-2-methyl-1H-imidazole

HRID 1005506

反応式

HRID 1005506 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[N:14]([CH2:15][O:16][CH2:17][CH2:18][OH:19])[C:13]([CH3:20])=[N:12][C:11]=2[CH:21]([CH3:23])[CH3:22])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:24][O:25][C:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]=1>>[CH3:8][C:6]1[CH:5]=[C:4]([S:9][C:10]2[N:14]([CH2:15][O:16][CH2:17][CH2:18][O:19][C:26]3([O:25][CH3:24])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)[C:13]([CH3:20])=[N:12][C:11]=2[CH:21]([CH3:23])[CH3:22])[CH:3]=[C:2]([CH3:1])[CH:7]=1

参加物

3

反応物 2

HCID 702641-MethoxycyclohexeneHCID 4781802-[5-(3,5-Dimethyl-phenylsulfanyl)-4-isopropyl-2-methyl-imidazol-1-ylmethoxy]-ethanol

生成物 1

HCID 158871855-(3,5-Dimethylphenylthio)-4-isopropyl-1-[2-(1-methoxycyclohexyloxy)ethoxymethyl)-2-methyl-1H-imidazole収率 74.9%

実験手順

The compound 1 (502 mg, 1.50 mmol) was converted to the acetal with 1-methoxycyclohexene (1.68 g, 15.0 mmol) in the same manner as the example 2 to give the compound 3 (502 mg, 72%).

出典と根拠

ORDレコード
ord-041186c113bc459a9d99051af14fa557
出典データセット
uspto-grants-2000_04
特許番号
US06054591

関連ノート

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