化工社化工社 化学情報印刷レポート · 研究参考用
Carbamate → 5-(3,5-Dichlorophenylthio)-4-isopropyl-1-(4-pyridylmethyl)-1H-imidazol-2-ylmethyl myristoylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbamate | HCID 276 | — |
| 反応物 | {5-[(3,5-Dichlorophenyl)sulfanyl]-4-isopropyl-1-((pyridin-4-YL)methyl)imidazol-2-YL}methanol | HCID 9844329 | — |
| 反応物 | Myristoyl isocyanate | HCID 18792057 | — |
| 生成物 | 5-(3,5-Dichlorophenylthio)-4-isopropyl-1-(4-pyridylmethyl)-1H-imidazol-2-ylmethyl myristoylcarbamate | HCID 69689012 | 46% |
反応手順
The compound 89 (245 mg, 0.6 mmol) was converted to the carbamate with myristoyl isocyanate (5 eq.) in the same manner as the example 66 to give the compound 94 (182 mg, 46%) as oil. Rf 0.41 (EtOAc).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06054591 |
| 出典データセット | uspto-grants-2000_04 |
| ORD ID | ord-96cfbe9e7b5241499fc6a48d123ef6e9 |
| 出典メモ | uspto-grants-2000_04 |