Potassium Carbonate → 6-Ethoxycarbonylamino-1-methyl-3,4-dihydroisoquinoline

HRID 1005685ノート

反応式

HRID 1005685 の反応式
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:8]=1)(=O)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>>[CH2:17]([O:16][C:14]([NH:13][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][CH:10]=1)[C:1]([CH3:2])=[N:4][CH2:5][CH2:6]2)=[O:15])[CH3:18]

参加物

3

反応物 2

HCID 11430Potassium CarbonateHCID 22674171N-Acetyl-N-(3-ethoxycarbonylaminophenethyl)amine

生成物 1

HCID 226741196-Ethoxycarbonylamino-1-methyl-3,4-dihydroisoquinoline

実験手順

Using 1.0 g of N-acetyl-N-(3-ethoxycarbonylaminophenethyl)amine (Preparation Example 30), cyclization reaction was conducted according to the procedure described in Heterocycles 31(2), 341 (1990). After the completion of the reaction, the reaction mixture was poured onto ice, the mixture was basified with potassium carbonate, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give the title compound as brown oil.

後処理

  1. customAfter the completion of the reaction
  2. additionthe reaction mixture was poured onto ice
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-ecefc55a51014799b27966792eb14a58
出典データセット
uspto-grants-2004_09
特許番号
US06787534B2

反応ノート

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