Triethylamine → HCID 178501652、化合物

HRID 1005729ノート

反応式

HRID 1005729 の反応式
[OH:1][C:2]1[C:3]([C:8]([O:10]C)=O)=[N:4][CH:5]=[CH:6][N:7]=1.C(N(CC)CC)C.Cl.[CH3:20][O:21][C:22](=[O:25])[CH2:23][NH2:24]>ClCCl>[OH:1][C:2]1[C:3]([C:8]([NH:24][CH2:23][C:22]([O:21][CH3:20])=[O:25])=[O:10])=[N:4][CH:5]=[CH:6][N:7]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 122755Glycine methyl ester hydrochlorideHCID 178499100HCID 178499100、化合物

生成物 1

HCID 178501652HCID 178501652、化合物収率 38.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In 6 mL of dichloromethane is suspended 0.30 g of methyl 3-hydroxy-2-pyrazinecaroxylate obtained according to the method described in literature [J. Heterocycl. Chem., 34, 27 (1997)]. To the suspension are successively added 0.54 mL of triethylamine and 0.29 g of glycine methyl ester hydrochloride. The resulting mixture is stirred at ambient temperature for 5 hours. After cooling, the solvent is distilled off under reduced pressure. The residue is purified by reverse phase column chromatography (eluent: water) to obtain 0.16 g of methyl 2-{[(3-hydroxy-2-pyrazinyl)-carbonyl]amino}acetate.

後処理

  1. customobtained
  2. temperatureAfter cooling
  3. distillationthe solvent is distilled off under reduced pressure
  4. customThe residue is purified by reverse phase column chromatography (eluent: water)

出典と根拠

ORDレコード
ord-aed0ecfc7b8e4ad19bc8c27d6476e211
出典データセット
uspto-grants-2004_09
特許番号
US06787544B2

反応ノート

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