2-(R)-{4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-N-hydroxy-3-methyl-butyramide → 2-(R)-{4-[5-(3,4-Dichlorophenyl)pyrimidin-2yl]piperazine-1-sulfonylmethyl}-N-hydroxy-3-methylbutyramide

HRID 1005905ノート

反応式

HRID 1005905 の反応式
FC1C=CC(C2C=NC(N3CCN(S(C[C@H](C(C)C)C([NH:27][OH:28])=O)(=O)=O)CC3)=NC=2)=CC=1.[Cl:32][C:33]1[CH:34]=[C:35]([C:40]2[CH:41]=[N:42][C:43]([N:46]3[CH2:51][CH2:50][N:49]([S:52]([CH2:55][C@H:56]([CH:60]([CH3:62])[CH3:61])[C:57](O)=[O:58])(=[O:54])=[O:53])[CH2:48][CH2:47]3)=[N:44][CH:45]=2)[CH:36]=[CH:37][C:38]=1[Cl:39]>>[Cl:32][C:33]1[CH:34]=[C:35]([C:40]2[CH:41]=[N:42][C:43]([N:46]3[CH2:47][CH2:48][N:49]([S:52]([CH2:55][C@H:56]([CH:60]([CH3:61])[CH3:62])[C:57]([NH:27][OH:28])=[O:58])(=[O:53])=[O:54])[CH2:50][CH2:51]3)=[N:44][CH:45]=2)[CH:36]=[CH:37][C:38]=1[Cl:39]

参加物

3

反応物 2

HCID 235197322-(R)-{4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-N-hydroxy-3-methyl-butyramideHCID 235197352-(R)-{4-[5-(3,4-Dichlorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-3-methylbutyric acid

生成物 1

HCID 235197272-(R)-{4-[5-(3,4-Dichlorophenyl)pyrimidin-2yl]piperazine-1-sulfonylmethyl}-N-hydroxy-3-methylbutyramide収率 29%

実験手順

Prepared according to the method for the preparation of 2-(R)-{4-[5-(4-fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-N-hydroxy-3-methylbutyramide, from 2-(R)-{4-[5-(3,4-dichlorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}-3-methylbutyric acid (0.270 g), to yield the title compound as a white solid (0.080 g, 29%).

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-96191c4c456a4c25b4d3790f5c4b59d4
出典データセット
uspto-grants-2004_09
特許番号
US06787536B2

反応ノート

読み込み中…