関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Pipecolic acid, (-)- | HCID 439227 | — |
| 生成物 | methyl (2S)-piperidine-2-carboxylate hydrochloride | HCID 13246232 | — |
反応手順
Thionyl chloride (0.58 ml) was added dropwise to a solution of L-pipecolinic acid (450 mg) in methanol at room temperature. The reaction mixture was stirred at 55° C. for 2 hours. The whole mixture was evaporated under reduced pressure to give (2S)-piperidine-2-carboxylic acid methyl ester hydrochloride as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06787543B2 |
|---|
| 出典データセット | uspto-grants-2004_09 |
|---|
| ORD ID | ord-6a6deb3a16944022b212e5e35fcbc918 |
|---|
| 出典メモ | uspto-grants-2004_09 |
|---|
