Water → 7-[(2-Hydroxy-1,1-dimethylethyl)amino]-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2(3H)-one

HRID 1006489ノート

反応式

HRID 1006489 の反応式
C[O:2][C:3]1[S:4][C:5]2[C:10]([NH:11][C:12]([CH3:16])([CH3:15])[CH2:13][OH:14])=[N:9][C:8]([S:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[N:7][C:6]=2[N:25]=1.O>O1CCOCC1.Cl>[OH:14][CH2:13][C:12]([NH:11][C:10]1[C:5]2[S:4][C:3](=[O:2])[NH:25][C:6]=2[N:7]=[C:8]([S:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:9]=1)([CH3:15])[CH3:16]

参加物

5

反応物 2

HCID 962WaterHCID 226712732-[[2-Methoxy-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1-propanol

生成物 1

HCID 99289397-[(2-Hydroxy-1,1-dimethylethyl)amino]-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2(3H)-one

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid触媒HCID 312751,4-Dioxane溶媒

反応条件

温度
45 °C

実験手順

To a solution of the product from example 1 step f) (0.21 g) in 1,4-dioxane (5 ml) was added water (0.1 ml) and concentrated hydrochloric acid (1 drop). The mixture heated at 45° C. for 3 hours then evaporated to dryness. Recrystallisation (acetonitrile) gave the title compound (0.110 g).

後処理

  1. customthen evaporated to dryness
  2. customRecrystallisation (acetonitrile)

出典と根拠

ORDレコード
ord-3ddca100a53a4f79a7a271f0f6ac8ce3
出典データセット
uspto-grants-2004_09
特許番号
US06790850B1

反応ノート

読み込み中…