1-(Bromomethyl)-2,3-difluoro-benzene → HCID 178508256、化合物

HRID 1006492

反応式

HRID 1006492 の反応式
CC(C)([O-])C.[K+].[NH2:7][C:8]1[S:9][C:10]2[C:15](=[O:16])[NH:14][C:13](=[S:17])[NH:12][C:11]=2[N:18]=1.[F:19][C:20]1[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22]Br>CS(C)=O>[NH2:7][C:8]1[S:9][C:10]2[C:15](=[O:16])[N:14]=[C:13]([S:17][CH2:22][C:21]3[CH:24]=[CH:25][CH:26]=[C:27]([F:28])[C:20]=3[F:19])[NH:12][C:11]=2[N:18]=1

参加物

5

反応物 3

HCID 5179841-(Bromomethyl)-2,3-difluoro-benzeneHCID 114583092-amino-5,6-dihydro-5-thioxo-thiazolo[4,5-d]pyrimidin-7(4H)-oneHCID 23665647Potassium tert-butoxide

生成物 1

HCID 178508256HCID 178508256、化合物

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

Potassium t-butoxide solution (0.45 ml of 1M solution in tetrahydrofuran) was added to a stirred solution of 2-amino-5,6-dihydro-5-thioxo-thiazolo[4,5-d]pyrimidin-7(4H)-one (0.09 g) [Cited: Indian J. Chem., Sect. B (1989), 28B(11), 964-5.] and 2,3-difluorobenzyl bromide in dimethyl sulphoxide (2 ml). After stirring for 3 days, the reaction mixture was poured onto water to give and the subtitle compound, isolated by filtration.

後処理

  1. additionthe reaction mixture was poured onto water
  2. customto give

出典と根拠

ORDレコード
ord-a7a75b0f10e0404594d76a55bd7a4c8b
出典データセット
uspto-grants-2004_09
特許番号
US06790850B1

関連ノート

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