Thiourea → HCID 22671284、化合物

HRID 1006506ノート

反応式

HRID 1006506 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12])[CH2:5]Br.NC(N)=[S:17]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:5][SH:17])[CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12]

参加物

4

反応物 2

HCID 2723790ThioureaHCID 27738494-(Bromomethyl)-2-chloro-1-(trifluoromethoxy)benzene

生成物 1

HCID 22671284HCID 22671284、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 3-chloro-4-(trifluoromethoxy)benzylbromide (5 g) in ethanol (100 ml) was added thiourea (5 g) and the mixture heated under reflux for 2 hours. The mixture was evaporated to dryness and the residue taken up into water (100 ml). To this solution was added sodium hydroxide pellets (3 g) and the mixture heated under reflux for 1 hour. The mixture was allowed to cool to room temperature and acidified with concentrated hydrochloric acid, the mixture was extracted with ether, dried and evaporated to give the subtitle compound as a colourless waxy solid (3.5 g).

後処理

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 2 hours
  3. customThe mixture was evaporated to dryness
  4. additionTo this solution was added sodium hydroxide pellets (3 g)
  5. temperaturethe mixture heated
  6. temperatureunder reflux for 1 hour
  7. extractionthe mixture was extracted with ether
  8. customdried
  9. customevaporated

出典と根拠

ORDレコード
ord-86ca4727cca049128d5ddab58d5558e1
出典データセット
uspto-grants-2004_09
特許番号
US06790850B1

反応ノート

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