Methanol → 7-Chloro-5-[(2,3-difluorophenylmethyl)thio]-2-methoxythiazolo[4,5-d]pyrimidine

HRID 1006508ノート

反応式

HRID 1006508 の反応式
Br[C:2]1[S:3][C:4]2[C:9]([Cl:10])=[N:8][C:7]([S:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=3[F:20])=[N:6][C:5]=2[N:21]=1.[OH-:22].[K+].[CH3:24]O>Cl>[Cl:10][C:9]1[C:4]2[S:3][C:2]([O:22][CH3:24])=[N:21][C:5]=2[N:6]=[C:7]([S:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:14]=2[F:20])[N:8]=1

参加物

5

反応物 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 226713342-Bromo-7-chloro-5-((2,3-difluorobenzyl)thio)thiazolo[4,5-d]pyrimidine

生成物 1

HCID 226713137-Chloro-5-[(2,3-difluorophenylmethyl)thio]-2-methoxythiazolo[4,5-d]pyrimidine

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid触媒

実験手順

The product of example 31 step a) (5.6 g) was suspended in methanol (150 ml) and potassium hydroxide powder (0.77 g) added. The whole was stirred at room temperature for 2 hours. The mixture was adjusted to pH 7 with a few drops of concentrated hydrochloric acid before it was evaporated to dryness. Purified by column chromatography (silica-3:2 to 1:1 isohexane/dichloromethane) to give white solid (2.0 g).

後処理

  1. customwas evaporated to dryness
  2. customPurified by column chromatography (silica-3:2 to 1:1 isohexane/dichloromethane)

出典と根拠

ORDレコード
ord-9414865e4b8044c0a4fe600fec071c31
出典データセット
uspto-grants-2004_09
特許番号
US06790850B1

反応ノート

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