関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | 2-Bromo-1-(bromomethyl)-3-methylbenzene | HCID 10934320 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(2-Bromo-3-methylphenyl)acetonitrile | HCID 22672613 | 44.1% |
反応手順
A mixture of 2-brom-3-methylbenzylbromide (25 g, 0.095 mol) and potassium cyanide (16 g, 0.25 mol) in dimethylformamide (100 ml) was stirred at 90° C. for 20 h. The solvent was evaporated under reduced pressure and to the residue were added toluene and water. The organic layer was separated washed with water, separated and evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel using methylene chloride as eluent gave 8.8 g (44%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06790960B2 |
|---|
| 出典データセット | uspto-grants-2004_09 |
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| ORD ID | ord-9ba3ef7949d34f6181be2d166926885e |
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| 出典メモ | uspto-grants-2004_09 |
|---|
