化工社化工社 化学情報印刷レポート · 研究参考用
4-Hydroxy-3-methoxybenzonitrile → 3,4-Dihydroxybenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxy-3-methoxybenzonitrile | HCID 78135 | — |
| 反応物 | Lithium Bromide | HCID 82050 | — |
| 反応物 | 3,4-Diethoxybenzonitrile | HCID 12946190 | — |
| 生成物 | 3,4-Dihydroxybenzonitrile | HCID 87065 | 79% |
反応手順
The preparation was carried out according to the process of Example 2a except that 3,4-diethoxybenzonitrile was used as the starting material instead of 3-methoxy-4-hydroxybenzonitrile, and 2-fold of lithium bromide (162.6 g, 1.88 mole) were added to form the reaction mixture. 3,4-Dihydroxybenzonitrile was obtained as a white solid with a yield of 79% and a purity of greater than 92% as indicated by HPLC analysis.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06790977B2 |
| 出典データセット | uspto-grants-2004_09 |
| ORD ID | ord-59cb6a1788d04c77932ef7acef6dc074 |
| 出典メモ | uspto-grants-2004_09 |