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Morpholine → 3-[4-(4-Morpholinyl)phenyl]isoquinolin-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Fluorobenzonitrile | HCID 14517 | — |
| 反応物 | N-methyl-2-toluamide | HCID 75111 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 3-[4-(4-Morpholinyl)phenyl]isoquinolin-1-one | HCID 22503318 | 41.5% |
反応手順
4-(4-Morpholinyl)benzonitrile obtained by reacting 4-fluorobenzonitrile (10.89 g) and morpholine (7.84 g) in the presence of potassium carbonate (12.42 g) in dimethyl sulf oxide (45 ml) was reacted with N-methyl-o-toluamide (8.019 g) according to Example 10-1, to give 6.840 g of 3-[4-(4-morpholinyl)phenyl]isoquinolin-1-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06790844B2 |
| 出典データセット | uspto-grants-2004_09 |
| ORD ID | ord-bfb04973d50f447d9915484061949813 |
| 出典メモ | uspto-grants-2004_09 |