4-(Dimethylamino)-2-methoxybenzaldehyde → 4-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-(2-methoxy-4-dimethylaminobenzylidene)thiosemicarbazide

HRID 1007278

反応式

HRID 1007278 の反応式
[CH:1]12[CH2:7][CH:4]([CH:5]=[CH:6]1)[CH2:3][CH:2]2[NH:8][C:9]([NH:11][NH2:12])=[S:10].[CH3:13][O:14][C:15]1[CH:22]=[C:21]([N:23]([CH3:25])[CH3:24])[CH:20]=[CH:19][C:16]=1[CH:17]=O>>[CH:1]12[CH2:7][CH:4]([CH:5]=[CH:6]1)[CH2:3][CH:2]2[NH:8][C:9](=[S:10])[NH:11][N:12]=[CH:17][C:16]1[CH:19]=[CH:20][C:21]([N:23]([CH3:25])[CH3:24])=[CH:22][C:15]=1[O:14][CH3:13]

参加物

3

反応物 2

HCID 2913504-(Dimethylamino)-2-methoxybenzaldehydeHCID 2740681N1-bicyclo[2.2.1]hept-5-en-2-ylhydrazine-1-carbothioamide

生成物 1

HCID 850689264-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-(2-methoxy-4-dimethylaminobenzylidene)thiosemicarbazide

実験手順

The title compound was prepared from a mixture of N1-bicyclo[2.2.1]hept-5-en-2-ylhydrazine-1-carbothioamide (100 mg, 0.6 mmol) and 2-methoxy-4-dimethylaminobenzaldehyde (97 mg, 0.72 mmol) similar to Example 3 and isolated as a yellow solid (60 mg, 29%). 1H NMR (CDCl3): 9.08 (s, 1H), 8.05 (s, 1H), 7.65 (brs, 1H), 7.45 (brs, 1H), 6.27 (brs, 1H), 6.22 (ddd, J=8.1, 5.1, 2.7 Hz, 2H), 6.00 (s, 1H), 4.32 (m, 1H), 3.82 (s, 3H), 3.03 (s, 6H), 2.93 (s, 1H), 1.85 (m, 1H), 1.64 (m, 1H), 1.54 (m, 1H), 1.41 (m, 1H).

出典と根拠

ORDレコード
ord-0e70a9042dc14722944cc804bd61310d
出典データセット
uspto-grants-2004_09
特許番号
US06794400B2

関連ノート

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