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(Formyloxy)acetonitrile → (s)-n-Formyl-beta-cyclopropylalanine tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (Formyloxy)acetonitrile | HCID 4205685 | — |
| 反応物 | (S)-tert-Butyl 2-amino-3-cyclopropylpropanoate | HCID 12018345 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (s)-n-Formyl-beta-cyclopropylalanine tert-butyl ester | HCID 12018346 | — |
反応手順
A mixture of 10 g (54 mmol) of (S)-β-cyclopropylalanine tert-butyl ester and 4.7 g (55.2 mmol) of cyanomethyl formate in 100 mL of dichloromethane was stirred at room temperature overnight. The residue obtained after removal of the solvent in vacuo was distilled in vacuo. Yield: 8.8 g (76%). Boiling point 120° C./40 Pa (0.3 torr).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06794517B2 |
| 出典データセット | uspto-grants-2004_09 |
| ORD ID | ord-fa7a2359d00246fbaccb855bb320c870 |
| 出典メモ | uspto-grants-2004_09 |