2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chlorophenyl)amide → 5-[5-(3-Chlorophenylsulfamoyl)-2-oxo-1,2-dihydroindol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-ylethyl)amide

HRID 1008203

反応式

HRID 1008203 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][S:9]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16](=[O:21])[CH2:15]3)(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[N:22]1([CH2:27][CH2:28][NH:29][C:30]([C:32]2[C:36]([CH3:37])=[C:35]([CH:38]=O)[NH:34][C:33]=2[CH3:40])=[O:31])[CH2:26][CH2:25][CH2:24][CH2:23]1>>[N:22]1([CH2:27][CH2:28][NH:29][C:30]([C:32]2[C:36]([CH3:37])=[C:35]([CH:38]=[C:15]3[C:14]4[C:18](=[CH:19][CH:20]=[C:12]([S:9](=[O:11])(=[O:10])[NH:8][C:4]5[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=5)[CH:13]=4)[NH:17][C:16]3=[O:21])[NH:34][C:33]=2[CH3:40])=[O:31])[CH2:26][CH2:25][CH2:24][CH2:23]1

参加物

3

反応物 2

HCID 90558432-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chlorophenyl)amideHCID 207617295-formyl-2,4-dimethyl-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrrole-3-carboxamide

生成物 1

HCID 672815835-[5-(3-Chlorophenylsulfamoyl)-2-oxo-1,2-dihydroindol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-ylethyl)amide収率 69.5%

実験手順

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)amide (120 mg, 0.38 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-ylethyl)amide (100 mg) to give 150 mg (69%) of the title compound as a yellow orange solid.

出典と根拠

ORDレコード
ord-438e1640aa984f249e569a86bb73aee5
出典データセット
uspto-grants-2004_09
特許番号
US06797725B2

関連ノート

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