関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Quinazoline | HCID 9210 | — |
| 反応物 | 4-Chloroquinoline | HCID 69140 | — |
| 反応物 | 4-(Nitrophenoxy)quinoline | HCID 21890535 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | HCID 178418390 | HCID 178418390 | — |
| 触媒 | HCID 178502593 | HCID 178502593 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(Aminophenoxy)quinoline | HCID 21890324 | — |
反応手順
Next, 4-chloroquinoline derivative or a corresponding quinazoline derivative is allowed to act on nitrophenol in the presence of a suitable solvent or in the absence of a solvent to synthesize a 4-(nitrophenoxy)quinoline derivative or a corresponding quinazoline derivative which is then stirred in a suitable solvent, for example, N,N-dimethylformamide, in the presence of a catalyst, for example, palladium hydroxide-carbon or palladium-carbon, in a hydrogen atmosphere to give a 4-(aminophenoxy)quinoline derivative or a corresponding quinazoline derivative. Alternatively, a 4-chloroquinoline derivative or a corresponding quinazoline derivative may be allowed to act on aminophenol in the presence of a base, for example, sodium hydride, to give a 4-(aminophenoxy)quinoline derivative or a corresponding quinazoline derivative.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06797823B1 |
|---|
| 出典データセット | uspto-grants-2004_09 |
|---|
| ORD ID | ord-fab7dff1898d4f44bed73e1912799e42 |
|---|
| 出典メモ | uspto-grants-2004_09 |
|---|
