7-Methoxy-2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride → 7-Methoxy-2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonic acid [1-(4-amino-thieno[3,2-c]pyridin-2-ylmethyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-amide
反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:12][CH2:11][CH2:10][N:9]([S:13](Cl)(=[O:15])=[O:14])[CH2:8][C:7]=2[CH:17]=1.[NH2:18][C:19]1[C:24]2[CH:25]=[C:26]([CH2:28][CH:29]([NH:39]S(C3C=CC(OC4CCOCC4)=CC=3)(=O)=O)[C:30]([N:32]3[CH2:37][CH2:36][CH:35]([CH3:38])[CH2:34][CH2:33]3)=[O:31])[S:27][C:23]=2[CH:22]=[CH:21][N:20]=1>>[NH2:18][C:19]1[C:24]2[CH:25]=[C:26]([CH2:28][CH:29]([NH:39][S:13]([N:9]3[CH2:8][C:7]4[CH:17]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=4[O:12][CH2:11][CH2:10]3)(=[O:15])=[O:14])[C:30]([N:32]3[CH2:33][CH2:34][CH:35]([CH3:38])[CH2:36][CH2:37]3)=[O:31])[S:27][C:23]=2[CH:22]=[CH:21][N:20]=1参加物
3
反応物 2
生成物 1
実験手順
This compound was prepared from 210 mg of 7-methoxy-2,3-dihydro-5H-benzo[f][1,4]-oxazepine-4-sulfonyl chloride and 210 mg of 30a using the procedure described for 58c. Yield: 70 mg (oil), (+)-FAB-MS: 560 (MH+).