4-Amino-2-(aminomethyl)furo[3,2-c]pyridine → [l-((4-amino-furo[3,2-c]pyridin-2-yl)methylamino)-2-oxopyrrolidin-3-(S)yl]carbamic acid tert-butyl ester

反応式

[C:1]([O:5][C:6](=[O:26])[NH:7][C@H:8]1[CH2:12][CH2:11][N:10](CC2C=C3C(C=CN=C3N)=CC=2)[C:9]1=[O:25])([CH3:4])([CH3:3])[CH3:2].[NH2:27][C:28]1[C:33]2[CH:34]=[C:35]([CH2:37][NH2:38])[O:36][C:32]=2[CH:31]=[CH:30][N:29]=1>>[C:1]([O:5][C:6](=[O:26])[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([NH:38][CH2:37][C:35]2[O:36][C:32]3[CH:31]=[CH:30][N:29]=[C:28]([NH2:27])[C:33]=3[CH:34]=2)[C:9]1=[O:25])([CH3:2])([CH3:3])[CH3:4]

参加物

反応物 2

HCID 226657294-Amino-2-(aminomethyl)furo[3,2-c]pyridine

HCID 54531194[1-(1-amino-7-isoquinolinylmethyl)-2-oxopyrrolidin-3-(S)yl]carbamic acid tert-butyl ester

生成物 1

HCID 69781651[l-((4-amino-furo[3,2-c]pyridin-2-yl)methylamino)-2-oxopyrrolidin-3-(S)yl]carbamic acid tert-butyl ester

実験手順

Using the procedure described in example 85i 166 mg of 4-amino-2-(aminomethyl)furo[3,2-c]pyridine was transformed into 150 mg of the title compound. MS ESI+: 347 (M+H).

出典と根拠

ORDレコード: ord-f08d66aaf2734f7f8b7e49868a753248
出典データセット: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06797710B2

反応ノート

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