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3-(Trifluoromethyl)piperidine → 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Trifluoromethyl)piperidine | HCID 2760776 | — |
| 反応物 | 4-(2-Butynyloxy)-6-chloropyrimidine | HCID 12137602 | — |
| 生成物 | 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine | HCID 57672951 | 61.4% |
反応手順
0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.25 g of 3-trifluoromethylpiperidine were mixed and left for 10 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.30 g of 4-(2-butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine (hereinafter, referred to as Compound (24)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07973028B2 |
| 出典データセット | uspto-grants-2011_07 |
| ORD ID | ord-fdf92ab7964b4e9a82d13494eee4ee19 |
| 出典メモ | uspto-grants-2011_07 |