Bromine → 5-Bromo-4-ethylthiazol-2-amine

HRID 1009024ノート

反応式

HRID 1009024 の反応式
[CH2:1]([C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1)[CH3:2].[Br:9]Br>S(=O)(=O)(O)O>[Br:9][C:7]1[S:6][C:5]([NH2:8])=[N:4][C:3]=1[CH2:1][CH3:2]

参加物

4

反応物 2

HCID 24408BromineHCID 123782054-Ethyl-1,3-thiazol-2-amine

生成物 1

HCID 665201935-Bromo-4-ethylthiazol-2-amine

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
0 °C

実験手順

The above prepared 4-ethyl-thiazol-2-ylamine (1.125 g, 8.77 mmol) was dissolved in 4.5 mL of 20% aq. sulfuric acid, cooled to 0° C., and treated with Br2 (0.494 mL, 1.1 eq.). After 10 Min., the reaction mixture was carefully poured onto crashed ice/Na2CO3, twofold extracted with ethyl acetate, washed with water, dried over sodium sulfate, and evaporated to dryness. Thereby, 1.306 g of the title compound was obtained as light brown viscous oil, sufficiently pure to be used for the next step.

後処理

  1. addition, the reaction mixture was carefully poured
  2. extractiontwofold extracted with ethyl acetate
  3. washwashed with water
  4. dry with materialdried over sodium sulfate
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-fa9f99eb0d5942bb87242111f3aa8147
出典データセット
uspto-grants-2011_07
特許番号
US07973051B2

反応ノート

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