tert-butyl N-(4-ethyl-5-methylsulfanyl-thiazol-2-yl)carbamate → HCID 86630962、化合物
反応式
C(OC(=O)[NH:7][C:8]1[S:9][C:10]([S:15][CH3:16])=[C:11]([CH2:13][CH3:14])[N:12]=1)(C)(C)C>Cl>[CH2:13]([C:11]1[N:12]=[C:8]([NH2:7])[S:9][C:10]=1[S:15][CH3:16])[CH3:14]参加物
3
反応条件
- 温度
- 30 °C
実験手順
The above prepared (4-ethyl-5-methylsulfanyl-thiazol-2-yl)-carbamic acid tert-butyl ester (1.067 g, 3.888 mmol) was treated with 20 mL of HCl (4 M in dioxane). After 48 h at RT the reaction mixture was evaporated to dryness and, since still some starting material was present, the procedure repeated, but this time the temperature was raised to 30° C. Careful evaporation and drying left 0.814 g of the title compound as hydrochloride.
後処理
- customAfter 48 h at RT the reaction mixture was evaporated to dryness
- customCareful evaporation
- customdrying
- waitleft 0.814 g of the title compound as hydrochloride
出典と根拠
- ORDレコード
- ord-d1011213f0be4f55ad73edfaaed38614
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07973051B2
反応ノート
読み込み中…