Phenethylamine → N-phenethyl phthalimide

反応式

[CH2:1]1[CH:8]([N:9]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:10]2=[O:11])C(=O)O[C:3](=O)[CH2:2]1.[CH2:20](N)[CH2:21][C:22]1C=CC=C[CH:23]=1>>[CH2:8]([N:9]1[C:10](=[O:11])[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:17]2[C:18]1=[O:19])[CH2:1][C:2]1[CH:3]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

反応物 2

HCID 1001Phenethylamine

HCID 92193N-Phthaloyl-DL-glutamic anhydride

生成物 1

HCID 348641N-phenethyl phthalimide

反応条件

温度: 177 °C

実験手順

With reference to Scheme 3 below, a mixture of N-phthaloyl-DL-glutamic anhydride and phenethylamine was heated in a 177° C. oil bath. The reaction mixture was purified by chromatography on a silica gel column to afford N-phenethylthalidomide (8) and N-phenethylphthalimide (9).

後処理

customThe reaction mixture was purified by chromatography on a silica gel column

出典と根拠

ORDレコード: ord-eba8ad6807f34076af8289b27ccb2ac3
出典データセット: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07973057B2

反応ノート

読み込み中…

参加物