関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Diethyl isopropylidenemalonate | HCID 81255 | — |
| 反応物 | HCID 178490607 | HCID 178490607 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Diethyl 2-(1-(4-methoxyphenyl)-2-methylpropan-2-yl)malonate | HCID 67304572 | — |
反応手順
Diethylisopropylidenemalonate (6.686 ml, 34.09 mmol) was dissolved in 300 ml Et2O and cooled to −78° C. 4-Methoxybenzylmagnesium chloride (150.000 ml, 37.50 mmol) was added and stirring was continued for 5 h. The temperature was warmed up to 0° C. The reaction was hydrolyzed with 0.5 M HCl and extracted 3×EtOAc. Glass col. Chromatography (10-50% EtOAc in Hex.) provided diethyl 2-(1-(4-methoxyphenyl)-2-methylpropan-2-yl)malonate. MS m/z: 323.1 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07973047B2 |
|---|
| 出典データセット | uspto-grants-2011_07 |
|---|
| ORD ID | ord-98206daa36f142a3baccedf54bbdc0d0 |
|---|
| 出典メモ | uspto-grants-2011_07 |
|---|
