Water → 5-(4-Hydroxy-benzylidene)-3-(1-methyl-cyclohexylmethyl)-thiazolidine-2,4-dione

関与物質

役割	名称	HCID	仕込み量
反応物	Water	HCID 962	—
反応物	Potassium Carbonate	HCID 11430	—
反応物	5-((4-Hydroxyphenyl)methylene)-2,4-thiazolidinedione	HCID 517822	—
反応物	(1-Methylcyclohexyl)methyl trifluoromethanesulfonate	HCID 24827766	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	5-(4-Hydroxy-benzylidene)-3-(1-methyl-cyclohexylmethyl)-thiazolidine-2,4-dione	HCID 74326904	42%

反応手順

A solution of compound vii (0.5 mmol), compound iii (0.6 mmol) and K2CO3 (0.65 mmol) were stirred in DMF (3 mL) at 80° C. for 4 hr, poured into water, extracted with ethyl acetate (3×10 mL), dried and concentrated. The residue was purified by chromatography, affording compound 9 in 42% yield. 1H NMR (300 MHz, CDCl3) δ 0.94 (s, 3H), 1.14-1.86 (m, 10H), 3.63 (s, 2H), 5.69 (s, 1H), 6.94 (d, J=8.40 Hz, 2H), 7.43 (d, J=8.40 Hz, 2H), 7.83 (s, 1H); HRMS exact mass of (M+Na)+, 354.1140 amu; observed mass of (M+Na)+, 354.1141 amu.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07973062B2
出典データセット	uspto-grants-2011_07
ORD ID	ord-e1a6e959fcfb453ab5f9771eaf39757e
出典メモ	uspto-grants-2011_07