1-Iodo-4-isocyanatobenzene → (R)-(4-iodo-phenyl)carbamic acid 1-cyclopropyl-ethyl ester
反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][CH:3]=1.[CH:11]1([C@H:14]([OH:16])[CH3:15])[CH2:13][CH2:12]1>C(Cl)Cl>[CH:11]1([C@H:14]([O:16][C:9](=[O:10])[NH:8][C:5]2[CH:6]=[CH:7][C:2]([I:1])=[CH:3][CH:4]=2)[CH3:15])[CH2:13][CH2:12]1参加物
4
実験手順
To a suspension of 4-iodophenylisocyanate (0.84 g, 3.5 mmol) in CH2Cl2 (6 mL) was added (R)-1-cyclopropylethanol (0.67 mL, 6.9 mmol). The solution was then directly subjected to silica gel chromatography (CH2Cl2) to provide (R)-(4-iodo-phenyl)carbamic acid 1-cyclopropyl-ethyl ester (1.05 g, 93%).
出典と根拠
- ORDレコード
- ord-a534d081ca3d430499b46a9dd48a676c
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07973069B2
反応ノート
読み込み中…