Benzenesulfonyl chloride, 2,4-dinitro- → N-(1-methylpyrazol-4-yl)-2,4-dinitrobenzenesulphonamide

HRID 1009744

反応式

HRID 1009744 の反応式
[N+:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[S:13](Cl)(=[O:15])=[O:14])([O-:3])=[O:2].[NH2:17][C:18]1[CH:19]=[N:20][N:21]([CH3:23])[CH:22]=1>C(Cl)Cl>[CH3:23][N:21]1[CH:22]=[C:18]([NH:17][S:13]([C:5]2[CH:6]=[CH:7][C:8]([N+:10]([O-:12])=[O:11])=[CH:9][C:4]=2[N+:1]([O-:3])=[O:2])(=[O:15])=[O:14])[CH:19]=[N:20]1

参加物

4

反応物 2

HCID 74255Benzenesulfonyl chloride, 2,4-dinitro-HCID 47709901-methyl-1H-pyrazol-4-amine

生成物 1

HCID 39874320N-(1-methylpyrazol-4-yl)-2,4-dinitrobenzenesulphonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
-5 °C

実験手順

2,4-Dinitrobenzenesulphonyl chloride (3.1 g) was added dropwise to a stirred solution of 4-amino-1-methylpyrazole (2.55 g) in methylene chloride (50 ml) that had been cooled to −5° C. The resultant mixture was stirred at this temperature for 5 minutes. The mixture was washed in turn with water, a 5% aqueous ammonium chloride solution, a saturated aqueous sodium bicarbonate solution and brine. The organic phase was dried over magnesium sulphate and filtered. There was thus obtained a solution of N-(1-methylpyrazol-4-yl)-2,4-dinitrobenzenesulphonamide; Mass Spectrum: M+H+ 328.

後処理

  1. washThe mixture was washed in turn with water
  2. dry with materialThe organic phase was dried over magnesium sulphate
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-a01adaf0bb424607bf14bf30efe2c6ba
出典データセット
uspto-grants-2011_07
特許番号
US07973164B2

関連ノート

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