1,3-dimethyl-1H-pyrazol-4-amine → HCID 67304971、化合物

HRID 1009757

反応式

HRID 1009757 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=O)=[C:11]([O:19][CH3:20])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:21][C:22]1[C:23]([CH3:28])=[N:24][N:25]([CH3:27])[CH:26]=1>>[CH3:27][N:25]1[CH:26]=[C:22]([NH:21][C:16](=[O:18])[CH2:15][C:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][C:11]=2[O:19][CH3:20])[C:23]([CH3:28])=[N:24]1

参加物

3

反応物 2

HCID 44310561,3-dimethyl-1H-pyrazol-4-amineHCID 110655714-Benzyloxy-2-methoxyphenylacetic acid

生成物 1

HCID 67304971HCID 67304971、化合物

実験手順

Using an analogous procedure to that described in the portion of Example 17 that is concerned with the preparation of starting materials, 2-(4-benzyloxy-2-methoxyphenyl)acetic acid was reacted with 4-amino-1,3-dimethylpyrazole to give N-(1,3-dimethylpyrazol-4-yl)-2-(4-benzyloxy-2-methoxyphenyl)acetamide; 1H NMR: (CDCl3) 2.06 (s, 3H), 3.62 (s, 2H), 3.76 (s, 3H), 3.88 (s, 3H), 5.07 (s, 2H), 6.58 (m, 1H), 6.61 (d, 1H), 7.17 (d, 1H), 7.38 (m, 6H), 7.79 (s, 1H); Mass Spectrum: M+H+ 366; which material was hydrogenated to give N-(1,3-dimethylpyrazol-4-yl)-2-(4-hydroxy-2-methoxyphenyl)acetamide; 1H NMR: (DMSOd6) 2.09 (s, 3H), 3.44 (s, 2H), 3.68 (s, 3H), 3.7 (s, 3H), 6.28 (m, 1H), 6.37 (d, 1H), 6.93 (d, 1H), 7.76 (d, 1H), 9.23 (br s, 1H), 9.3 (br s, 1H); Mass Spectrum: M+H+ 276.

出典と根拠

ORDレコード
ord-55a8eccc318843f8a08612aece80a4c6
出典データセット
uspto-grants-2011_07
特許番号
US07973164B2

関連ノート

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