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Sodium Hydroxide → 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Tert-Butylaniline | HCID 69861 | — |
| 反応物 | 4-Chloro-3-methoxy-2-methylpyridine | HCID 10583046 | — |
| 溶媒 | Phenol | HCID 996 | — |
| 生成物 | 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine | HCID 19693953 | — |
反応手順
7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723450 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-ed5d30e63cae482aa9ed8a44a63361f9 |
| 出典メモ | uspto-grants-1998_03 |