関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Nitrophenol | HCID 980 | — |
| 反応物 | 2,6-Lutidine | HCID 7937 | — |
| 反応物 | 4-Chloro-6-cyano-7-(2-methoxyethoxy)quinoline | HCID 22646522 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 6-Cyano-7-(2-methoxyethoxy)-4-(4-nitrophenoxy)quinoline | HCID 22936341 | 43.1% |
反応手順
A mixture of 4-chloro-6-cyano-7-(2-methoxyethoxy)quinoline (3 g), 4-nitrophenol (3.17 g) and 2,6-lutidine (2.7 ml) was heated and stirred in an oil bath at 155° C. for 1.5 hours. After completion of the reaction, ethyl acetate was added, and the precipitated solid was filtered out. The solid was washed with 1N sodium hydroxide water and then with water and dried to obtain 1.8 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07973160B2 |
|---|
| 出典データセット | uspto-grants-2011_07 |
|---|
| ORD ID | ord-1ae2d0f342104e3d83030d30a2fbd348 |
|---|
| 出典メモ | uspto-grants-2011_07 |
|---|
