Methyl 2-(benzyloxy)-4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzoate → Methyl 7-(benzyloxy)-4-oxo-1,4-dihydro-6-quinolinecarboxylate

HRID 1010307ノート

反応式

HRID 1010307 の反応式
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]([NH:19][CH:20]=[C:21]2[C:26](=[O:27])OC(C)(C)OC2=O)[CH:16]=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:16]([C:26](=[O:27])[CH:21]=[CH:20][NH:19]2)=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 22936598Methyl 2-(benzyloxy)-4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzoate

生成物 1

HCID 22936245Methyl 7-(benzyloxy)-4-oxo-1,4-dihydro-6-quinolinecarboxylate収率 61.7%

試薬・触媒・溶媒 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)溶媒

反応条件

温度
200 °C

実験手順

After adding Dowtherm A (160 ml) to methyl 2-(benzyloxy)-4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzoate (15.477 g, 37.6 mmol), the mixture was stirred at 200° C. for 1 hour. Upon cooling to room temperature, the precipitated crystals were filtered, washed with diethyl ether and blow-dried to obtain the title compound (7.19 g, 23.2 mmol, 61.80).

後処理

  1. temperatureUpon cooling to room temperature
  2. filtrationthe precipitated crystals were filtered
  3. washwashed with diethyl ether
  4. customblow-dried

出典と根拠

ORDレコード
ord-3be34298f9104174883f6925be4b5acb
出典データセット
uspto-grants-2011_07
特許番号
US07973160B2

反応ノート

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