Hydrochloric Acid → 5-(2-Hydroxyethyl)-5-azaspiro[2.4]heptan-7-one
反応式
[OH:1][CH2:2][CH2:3][N:4]1[CH2:10][C:7]2([CH2:9][CH2:8]2)[C:6]2(OCC[O:11]2)[CH2:5]1.Cl>CC(C)=O>[OH:1][CH2:2][CH2:3][N:4]1[CH2:5][C:6](=[O:11])[C:7]2([CH2:8][CH2:9]2)[CH2:10]1参加物
4
実験手順
The above product from Example 1 (100 mg) was mixed with 1N HCl (4 ml) and acetone (20 ml). The reaction was refluxed overnight and evaporated. The solution was basified with 2N NaOH and extracted with EtOAc. The combined organic layer was washed with H2O followed by brine, dried over Na2SO4 and evaporated. The residue was purified by column chromatography to give title compound. Mass: (M+1), 156
後処理
- temperatureThe reaction was refluxed overnight
- customevaporated
- extractionextracted with EtOAc
- washThe combined organic layer was washed with H2O
- dry with materialdried over Na2SO4
- customevaporated
- customThe residue was purified by column chromatography
出典と根拠
- ORDレコード
- ord-336fb71995f84edb91aa84ed028f7bfc
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07977346B2
反応ノート
読み込み中…