Isobutyryl chloride → 6-Isopropyl-5-Oxa-7,13-Diazatetracyclo[9.3.1.02,10.04,8]Pentadeca-2(10),3,6,8-Tetraene Hydrochloride

関与物質

反応手順

2,2,2-Trifluoro-1-(4-hydroxy-5-amino-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-ethanone and isobutyryl chloride were converted to the title compound following the procedures described in Example 54. (TLC 25% ethyl acetate/hexanes Rf 0.14). 1H NMR (400 MHz, CD3OD) δ 7.65 (2H), 3.49 (br s, 2H), 3.41 (d, J=12.0 Hz, 2H), 3.33–3.19 (3H), 2.45 (m, 1H), 2.18 (d, J=11.5 Hz, 1H), 1.45 (d, J=7.0 Hz, 6H). APCI MS m/e 243.2 [(M+1)+]. (HCl salt) M.p. 249–251° C.

情報源と証拠