Sodium Methoxide → HCID 57699783、化合物

HRID 1010958ノート

反応式

HRID 1010958 の反応式
Br[C:2]1[N:3]([CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)[C:4]2[C:9]([N:10]=1)=[C:8]([NH2:11])[N:7]=[C:6]([O:12][CH2:13][CH2:14][CH:15]([CH3:17])[CH3:16])[N:5]=2.[CH3:24][O-:25].[Na+]>CCOC(C)=O>[CH3:16][CH:15]([CH3:17])[CH2:14][CH2:13][O:12][C:6]1[N:5]=[C:4]2[C:9]([N:10]=[C:2]([O:25][CH3:24])[N:3]2[CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)=[C:8]([NH2:11])[N:7]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 576996758-Bromo-2-[(3-methylbutyl)oxy]-9-(tetrahydro-2H-Pyran-2-yl)-9H-Purin-6-amine

生成物 1

HCID 57699783HCID 57699783、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 8-bromo-2-[(3-methylbutyl)oxy]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (314 mg) was added sodium methoxide solution (0.460 mL, 30% wt. MeOH) and the mixture was stirred at reflux for 4 h. The reaction was allowed to cool and was concentrated in vacuo to give an orange residue. The residue was taken up in EtOAc (20 mL) and was extracted with saturated ammonium chloride solution (20 mL), followed by water (20 mL). The organics were separated, dried over MgSO4, filtered and concentrated in vacuo to give the title compound as a light orange solid (210 mg).

後処理

  1. temperatureat reflux for 4 h
  2. temperatureto cool
  3. concentrationwas concentrated in vacuo
  4. customto give an orange residue
  5. extractionwas extracted with saturated ammonium chloride solution (20 mL)
  6. customThe organics were separated
  7. dry with materialdried over MgSO4
  8. filtrationfiltered
  9. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-010b1a3da70b47dcbc620ff88b2302d7
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

反応ノート

読み込み中…