Triethylamine → HCID 22402475、化合物

HRID 1010992

反応式

HRID 1010992 の反応式
[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][OH:8])[CH2:2]1.C(N(CC)CC)C.[S:16](Cl)([CH3:19])(=[O:18])=[O:17]>ClCCl>[CH3:19][S:16]([O:8][CH2:7][CH:3]1[CH2:4][CH2:5][CH2:6][O:1][CH2:2]1)(=[O:18])=[O:17]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 85769Tetrahydro-2H-pyran-3-methanol

生成物 1

HCID 22402475HCID 22402475、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To tetrahydro-2H-pyran-3-ylmethanol (4.92 g) in dry dichloromethane (140 ml) at 0° C. and under nitrogen, was added anhydrous triethylamine (13.6 ml) in one go, followed by mesyl chloride (4.3 ml) dropwise over 5 minutes. The reaction was allowed to warm to room temperature and stirred at this temperature overnight. The reaction was quenched with saturated aqueous sodium bicarbonate (50 ml). The organic layer was separated, passed through a hydrophobic frit to dry and concentrated in vacuo to yield a red oil (8.8 g).

後処理

  1. customThe reaction was quenched with saturated aqueous sodium bicarbonate (50 ml)
  2. customThe organic layer was separated
  3. customto dry
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-da1ea2a94585412492498f6165dd4248
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

関連ノート

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