4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine → 4-(4-tert-Butylcyclohexylamino)-3-methoxy-2-methylpyridine

HRID 1011

反応式

HRID 1011 の反応式
[C:1]([C:5]1[CH:20]=[CH:19][C:8]([NH:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[C:11]=2[O:17][CH3:18])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.Cl.O>[C:1]([CH:5]1[CH2:20][CH2:19][CH:8]([NH:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[C:11]=2[O:17][CH3:18])[CH2:7][CH2:6]1)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 1

HCID 196939534-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

生成物 1

HCID 544512624-(4-tert-Butylcyclohexylamino)-3-methoxy-2-methylpyridine

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

1 g of 4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine in 20 ml of methanol, 3.7 ml of 2N HCl and 1.3 ml of water are hydrogenated at room temperature and normal pressure until absorption of hydrogen has ended using 1 g of rhodium on alumina (5% strength). After filtering and concentrating 1 g of syrup remains=100% isomer mixture.

後処理

  1. customare hydrogenated at room temperature
  2. customnormal pressure until absorption of hydrogen
  3. filtrationAfter filtering
  4. concentrationconcentrating 1 g of syrup

出典と根拠

ORDレコード
ord-61a0177588e440db829d21a8578b91c1
出典データセット
uspto-grants-1998_03
特許番号
US05723450

関連ノート

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