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Water → 3,3-Dimethoxypropanoic acid lithium salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Methyl 3,3-dimethoxypropionate | HCID 81924 | — |
| 反応物 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3,3-Dimethoxypropanoic acid lithium salt | HCID 87665280 | 98.7% |
反応手順
(Related to methods described in Alabaster, C. T. et. al., J. Med. Chem. 1988, 31, 2048–2056.) 3,3-Dimethoxypropanoic acid methyl ester (14.25 g, 96.2 mmol) in THF (100 mL) was treated with LiOH.H2O (2.5 g, 106 mmol) and H2O (2 mL). The mixture was brought to reflux for 4 hours, cooled to room temperature and azeotropically dried from THF (4 times) to provide white solids (13.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091372B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-1760007316da4df791d25f5e9c52543d |
| 出典メモ | uspto-grants-2006_08 |