Hydrochloric Acid → 6-Amino-2-butyloxy-9-[(2,2-dimethyltetrahydro-2H-Pyran-4-yl)methyl]-7,9-dihydro-8H-Purin-8-one

HRID 1011172ノート

反応式

HRID 1011172 の反応式
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24]C)[N:12]2[CH2:15][CH:16]2[CH2:21][CH2:20][O:19][C:18]([CH3:23])([CH3:22])[CH2:17]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl>CO.O1CCOCC1>[NH2:26][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:24])[N:12]2[CH2:15][CH:16]1[CH2:21][CH2:20][O:19][C:18]([CH3:23])([CH3:22])[CH2:17]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 576996052-Butyloxy-9-[(2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl]-8-methoxy-9H-purin-6-amine

生成物 1

HCID 576996476-Amino-2-butyloxy-9-[(2,2-dimethyltetrahydro-2H-Pyran-4-yl)methyl]-7,9-dihydro-8H-Purin-8-one収率 78.8%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of 2-butyloxy-9-[(2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl]-8-methoxy-9H-purin-6-amine (161 mg) in methanol (1 mL) was treated with 4N HCl in 1,4-dioxane (0.5 mL) for 1 h. The reaction was evaporated and the residue treated with water then basified with saturated sodium bicarbonate solution. The resulting solid was filtered, washed with water and dried to give the title compound (122 mg).

後処理

  1. customThe reaction was evaporated
  2. additionthe residue treated with water
  3. filtrationThe resulting solid was filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-7119fe8618e44ac5862c073ac399e21d
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

反応ノート

読み込み中…