Hydrochloric Acid → 6-Amino-2-(butylamino)-9-[2-(tetrahydro-2H-Pyran-2-yl)ethyl]-7,9-dihydro-8H-Purin-8-one

HRID 1011175

反応式

HRID 1011175 の反応式
[CH2:1]([NH:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:23]C)[N:12]2[CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][O:18]2)=[C:8]([NH2:25])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl.O.C(=O)(O)[O-].[Na+]>CO.O1C=COC=C1>[NH2:25][C:8]1[N:7]=[C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:23])[N:12]2[CH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][O:18]1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 516892Sodium BicarbonateHCID 57699622N2-Butyl-8-(methoxy)-9-[2-(tetrahydro-2H-pyran-2-yl)ethyl]-9H-Purine-2,6-diamine

生成物 1

HCID 576996906-Amino-2-(butylamino)-9-[2-(tetrahydro-2H-Pyran-2-yl)ethyl]-7,9-dihydro-8H-Purin-8-one

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 789681,4-Dioxin溶媒

実験手順

A solution of N2-butyl-8-(methoxy)-9-[2-(tetrahydro-2H-pyran-2-yl)ethyl]-9H-purine-2,6-diamine (54 mg) in methanol (1 ml) was treated with 4N HCl in dioxin (0.5 ml) and stood for 1.5 h. The solvents were stripped and the residue treated with water and made basic with saturated aqueous sodium bicarbonate. The precipitated material was filtered, washed with water and dried to give the title compound as a solid, yield 22.5 mg.

後処理

  1. filtrationThe precipitated material was filtered
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-6838312a14de4624b0f2973c624f9431
出典データセット
uspto-grants-2011_07
特許番号
US07977344B2

関連ノート

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