Boron tribromide → 7-Hydroxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline

HRID 1011428ノート

反応式

HRID 1011428 の反応式
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]3[O:14][CH2:15][C:16]([CH3:19])([CH3:18])[N:17]=3)[CH:9]=[N:10]2)=[CH:5][CH:4]=1.B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]3[O:14][CH2:15][C:16]([CH3:19])([CH3:18])[N:17]=3)[CH:9]=[N:10]2)=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 231597597-Methoxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline

生成物 1

HCID 1356182107-Hydroxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 7-methoxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline (2.56 g, 10 mmol) prepared in stage A and BBr3 (7.41 g, 30 mmol) in dichloromethane (40 mL) are stirred for 12 hours at room temperature. The mixture was quenched with saturated sodium hydrogen carbonate. Extraction with dichloromethane, drying (MgSO4) and evaporation furnished the desired compound.

後処理

  1. customThe mixture was quenched with saturated sodium hydrogen carbonate
  2. extractionExtraction with dichloromethane
  3. customdrying
  4. custom(MgSO4) and evaporation

出典と根拠

ORDレコード
ord-f08bfad8e287479db8bc5f23ab85c845
出典データセット
uspto-grants-2011_07
特許番号
US07977354B2

反応ノート

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