Sodium Chloride → 2-Hydroxypropyl-Beta-Cyclodextrin

HRID 1011449

反応式

HRID 1011449 の反応式
[CH2:1]([OH:77])[C@H:2]1[O:7][C@@H:6]2[O:8][C@H:9]3[C@H:14]([OH:15])[C@@H:13]([OH:16])[C@@H:12]([O:17][C@H:18]4[C@H:23]([OH:24])[C@@H:22]([OH:25])[C@@H:21]([O:26][C@H:27]5[C@H:32]([OH:33])[C@@H:31]([OH:34])[C@@H:30]([O:35][C@H:36]6[C@H:41]([OH:42])[C@@H:40]([OH:43])[C@@H:39]([O:44][C@H:45]7[C@H:50]([OH:51])[C@@H:49]([OH:52])[C@@H:48]([O:53][C@H:54]8[C@H:60]([OH:61])[C@@H:59]([OH:62])[C@@H:57]([O:58][C@H:3]1[C@H:4]([OH:76])[C@H:5]2[OH:75])[O:56][C@@H:55]8[CH2:63][OH:64])[O:47][C@@H:46]7[CH2:65][OH:66])[O:38][C@@H:37]6[CH2:67][OH:68])[O:29][C@@H:28]5[CH2:69][OH:70])[O:20][C@@H:19]4[CH2:71][OH:72])[O:11][C@@H:10]3[CH2:73][OH:74].[Na+].[Cl-]>>[CH3:3][CH:2]([OH:7])[CH2:1][O:70][CH2:69][C@H:28]1[O:29][C@@H:30]2[O:35][C@H:36]3[C@H:41]([OH:42])[C@@H:40]([OH:43])[C@@H:39]([O:44][C@H:45]4[C@H:50]([OH:51])[C@@H:49]([OH:52])[C@@H:48]([O:53][C@H:54]5[C@H:60]([OH:61])[C@@H:59]([OH:62])[C@@H:57]([O:58][C@H:3]6[C@H:4]([OH:76])[C@@H:5]([OH:75])[C@@H:6]([O:8][C@H:9]7[C@H:14]([OH:15])[C@@H:13]([OH:16])[C@@H:12]([O:17][C@H:18]8[C@H:23]([OH:24])[C@@H:22]([OH:25])[C@@H:21]([O:26][C@H:27]1[C@H:32]([OH:33])[C@H:31]2[OH:34])[O:20][C@@H:19]8[CH2:71][O:72][CH2:60][CH:54]([OH:53])[CH3:55])[O:11][C@@H:10]7[CH2:73][O:74][CH2:32][CH:27]([OH:26])[CH3:28])[O:7][C@@H:2]6[CH2:1][O:77][CH2:14][CH:9]([OH:8])[CH3:10])[O:56][C@@H:55]5[CH2:63][O:64][CH2:37][CH:36]([OH:35])[CH3:41])[O:47][C@@H:46]4[CH2:65][O:66][CH2:46][CH:45]([OH:44])[CH3:50])[O:38][C@@H:37]3[CH2:67][O:68][CH2:19][CH:18]([OH:17])[CH3:23]

参加物

3

反応物 2

HCID 5234Sodium ChlorideHCID 444041beta-Cyclodextrin

生成物 1

HCID 140496892-Hydroxypropyl-Beta-Cyclodextrin

実験手順

61 mg (0.21 mmol) of compound described in example 67 and 1.47 g of hydroxypropyl-beta-cyclodextrin (DS 0.58-Mw 1386 g·L−1) were dissolved in 15 mL of dichloromethane and 10 mL of methanol. The limpid mixture was evaporated under reduced pressure at room temperature. The solid obtained was then dissolved in 3 mL of MilliQ water and filtered through filter with 45 micron pore size. The filter was rinsed with 9 mL of MilliQ water. The aqueous solution was then freeze dried giving 2 g of a pale yellow powder containing 4 wt % of product described in example 67 (mol/mol ratio for the complex “dihydro-compound/beta-cyclodextrine”: ⅕). The included molecule is now soluble (20 g·L−1) in a 9 wt % NaCl aqueous solution.

後処理

  1. additioncontaining 4 wt % of product

出典と根拠

ORDレコード
ord-8befa925380e4dbd92235ec9a460a3ee
出典データセット
uspto-grants-2011_07
特許番号
US07977354B2

関連ノート

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