Water → 2-Aminocarbonylamino-5-(4-bromophenyl)-4-chloropyrrole-3-carboxamide

HRID 1011577ノート

反応式

HRID 1011577 の反応式
[Cl:1]N1C(=O)CCC1=O.[NH2:9][C:10]([NH:12][C:13]1[NH:14][C:15]([C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)=[CH:16][C:17]=1[C:18]([NH2:20])=[O:19])=[O:11].O>CN(C)C=O>[NH2:9][C:10]([NH:12][C:13]1[NH:14][C:15]([C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)=[C:16]([Cl:1])[C:17]=1[C:18]([NH2:20])=[O:19])=[O:11]

参加物

5

反応物 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 250057042-Aminocarbonylamino-5-(4-bromophenyl)pyrrole-3-carboxamide

生成物 1

HCID 592858832-Aminocarbonylamino-5-(4-bromophenyl)-4-chloropyrrole-3-carboxamide収率 51%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

N-Chlorosuccinimide (48 mg, 0.36 mmol) was added to a solution of 2-aminocarbonylamino-5-(4-bromophenyl)pyrrole-3-carboxamide (Compound No. 1-1, 97 mg, 0.30 mmol) in anhydrous N,N-dimethylformamide (2 mL), and the mixture was stirred overnight at 50° C. After cooling, water (4 mL) was added thereto, the precipitated solid was filtered off, and washed with water (5 mL). The obtained solid was dried under reduced pressure to give the target compound (54 mg) as a pale brown solid (Yield 51%).

後処理

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid was filtered off
  3. washwashed with water (5 mL)
  4. customThe obtained solid was dried under reduced pressure

出典と根拠

ORDレコード
ord-4d0288762c754547860d5c69e09d62bf
出典データセット
uspto-grants-2011_07
特許番号
US07977371B2

反応ノート

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