Citric Acid → 1-butyl-N,N-dimethyl-4,4-bis(3-methyl-5-(trifluoromethyl)-1H-indol-2-yl)cyclohexanamine 2-hydroxypropane-1,2,3-tricarboxylate

HRID 1011622ノート

反応式

HRID 1011622 の反応式
[CH2:1]([C:5]1([N:39]([CH3:41])[CH3:40])[CH2:10][CH2:9][C:8]([C:25]2[NH:26][C:27]3[C:32]([C:33]=2[CH3:34])=[CH:31][C:30]([C:35]([F:38])([F:37])[F:36])=[CH:29][CH:28]=3)([C:11]2[NH:12][C:13]3[C:18]([C:19]=2[CH3:20])=[CH:17][C:16]([C:21]([F:24])([F:23])[F:22])=[CH:15][CH:14]=3)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4].[C:42]([OH:54])(=[O:53])[CH2:43][C:44]([CH2:49][C:50]([OH:52])=[O:51])([C:46]([OH:48])=[O:47])[OH:45]>C(O)C>[OH:45][C:44]([C:46]([OH:48])=[O:47])([CH2:49][C:50]([OH:52])=[O:51])[CH2:43][C:42]([OH:54])=[O:53].[CH2:1]([C:5]1([N:39]([CH3:41])[CH3:40])[CH2:10][CH2:9][C:8]([C:11]2[NH:12][C:13]3[C:18]([C:19]=2[CH3:20])=[CH:17][C:16]([C:21]([F:22])([F:24])[F:23])=[CH:15][CH:14]=3)([C:25]2[NH:26][C:27]3[C:32]([C:33]=2[CH3:34])=[CH:31][C:30]([C:35]([F:38])([F:36])[F:37])=[CH:29][CH:28]=3)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 2

HCID 311Citric AcidHCID 445175681-butyl-N,N-dimethyl-4,4-bis(3-methyl-5-(trifluoromethyl)-1H-indol-2-yl)cyclohexanamine

生成物 1

HCID 445175671-butyl-N,N-dimethyl-4,4-bis(3-methyl-5-(trifluoromethyl)-1H-indol-2-yl)cyclohexanamine 2-hydroxypropane-1,2,3-tricarboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

1-butyl-N,N-dimethyl-4,4-bis(3-methyl-5-(trifluoromethyl)-1H-indol-2-yl)cyclohexanamine (100 mg, 0.17 mmol) was dissolved in ethanol (10 ml) and mixed with citric acid (36 mg, 0.187 mmol) dissolved in hot ethanol (3 ml). The clear colourless solution was stirred for 48 h and then concentrated to low volume. After adding diethyl ether (10 ml), the mixture was stirred for 2 h at RT and the precipitate was then aspirated.

後処理

  1. concentrationconcentrated to low volume
  2. additionAfter adding diethyl ether (10 ml)
  3. stirringthe mixture was stirred for 2 h at RT

出典と根拠

ORDレコード
ord-7dd5d2d7c7404608aa092da276995103
出典データセット
uspto-grants-2011_07
特許番号
US07977370B2

反応ノート

読み込み中…