3-(Diethylamino)pyrrolidine → [Rac]-(1-{3-[(e)-2-(4-chloro-phenyl)-vinyl]-phenyl}-3,5-diethyl-1h-pyrazol-4-yl)-(3-diethylamino-pyrrolidin-1-yl)-methanone

HRID 1011889ノート

反応式

HRID 1011889 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[CH:11]=[C:12]([N:16]3[C:20]([CH2:21][CH3:22])=[C:19]([C:23](O)=[O:24])[C:18]([CH2:26][CH3:27])=[N:17]3)[CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.[CH2:28]([N:30]([CH2:36][CH3:37])[CH:31]1[CH2:35][CH2:34][NH:33][CH2:32]1)[CH3:29]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[CH:11]=[C:12]([N:16]3[C:20]([CH2:21][CH3:22])=[C:19]([C:23]([N:33]4[CH2:34][CH2:35][CH:31]([N:30]([CH2:36][CH3:37])[CH2:28][CH3:29])[CH2:32]4)=[O:24])[C:18]([CH2:26][CH3:27])=[N:17]3)[CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 199619953-(Diethylamino)pyrrolidineHCID 673139751-{3-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenyl}-3,5-diethyl-1H-pyrazole-4-carboxylic acid2 回

生成物 1

HCID 57555065[Rac]-(1-{3-[(e)-2-(4-chloro-phenyl)-vinyl]-phenyl}-3,5-diethyl-1h-pyrazol-4-yl)-(3-diethylamino-pyrrolidin-1-yl)-methanone

実験手順

In analogy to the procedure described for example 2, 1-{3-[(E)-2-(4-chloro-phenyl)-vinyl]-phenyl}-3,5-diethyl-1H-pyrazole-4-carboxylic acid (intermediate 1) and [rac]-diethyl-pyrrolidin-3-yl-amine gave the title compound as colorless oil. MS: 505.3 (MH+, 1 Cl).

出典と根拠

ORDレコード
ord-b5bd23f8e71647e588fe80ea173f0a52
出典データセット
uspto-grants-2011_07
特許番号
US07977358B2

反応ノート

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