3,4-Dichlorobenzeneboronic acid → HCID 57554968、化合物

HRID 1011912

反応式

HRID 1011912 の反応式
Br[C:2]1[CH:3]=[C:4]([C:8]2[N:12]([CH3:13])[N:11]=[C:10]([C:14]([N:16]3[CH2:20][CH2:19][CH:18]([N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[CH2:17]3)=[O:15])[C:9]=2[CH3:26])[CH:5]=[CH:6][CH:7]=1.[Cl:27][C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[CH:32][C:33]=1[Cl:34]>>[Cl:27][C:28]1[CH:29]=[C:30]([C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([C:8]3[N:12]([CH3:13])[N:11]=[C:10]([C:14]([N:16]4[CH2:20][CH2:19][CH:18]([N:21]([CH2:22][CH3:23])[CH2:24][CH3:25])[CH2:17]4)=[O:15])[C:9]=3[CH3:26])[CH:3]=2)[CH:31]=[CH:32][C:33]=1[Cl:34]

参加物

3

反応物 2

HCID 27343303,4-Dichlorobenzeneboronic acidHCID 67315151[5-(3-bromo-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone

生成物 1

HCID 57554968HCID 57554968、化合物収率 55%

実験手順

In analogy to the procedure described in example 14C], [5-(3-bromo-phenyl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone and 3,4-dichlorophenylboronic acid gave [5-(3′,4′-dichloro-biphenyl-3-yl)-1,4-dimethyl-1H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone in 55% yield as light brown foam. MS: 485.2 (MH+, 2 Cl).

出典と根拠

ORDレコード
ord-d15b8aff07b74f91a3be06d4c810f089
出典データセット
uspto-grants-2011_07
特許番号
US07977358B2

関連ノート

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