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trans-2-(4-Chlorophenyl)vinylboronic acid → (1-{3-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenyl}-3,5-dimethyl-1H-pyrazol-4-yl)-(3-diethylamino-pyrrolidin-1-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | trans-2-(4-Chlorophenyl)vinylboronic acid | HCID 642694 | — |
| 反応物 | [1-(3-Bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 67313795 | — |
| 生成物 | (1-{3-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenyl}-3,5-dimethyl-1H-pyrazol-4-yl)-(3-diethylamino-pyrrolidin-1-yl)-methanone | HCID 57554998 | 67% |
反応手順
In analogy to the procedure described in Example 14C], [1-(3-bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone (Example 28A]) and trans-2-(4-chlorophenyl)vinylboronic acid gave the title compound in 67% yield as light brown foam. MS: 477.3 (MH+, 1 Cl).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07977358B2 |
| 出典データセット | uspto-grants-2011_07 |
| ORD ID | ord-04b8153fdbc94b5e99b877891c9a8e96 |
| 出典メモ | uspto-grants-2011_07 |