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m-Chlorophenylhydrazine hydrochloride → 1-(3-chlorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | m-Chlorophenylhydrazine hydrochloride | HCID 75331 | — |
| 反応物 | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| 生成物 | 1-(3-chlorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 9965472 | 58% |
反応手順
In analogy to the procedure described in Example 38A], 3-chlorophenylhydrazine hydrochloride and ethyl diacetoacetate gave the title compound after purification by flash column chromatography (n-heptane:EtOAc 9:1-1:1) in 58% yield as light yellow solid. MS: 279.0 (MH+, 1 Cl).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07977358B2 |
| 出典データセット | uspto-grants-2011_07 |
| ORD ID | ord-59f743d999b741b3a2f97438755cde7a |
| 出典メモ | uspto-grants-2011_07 |