Hydrochloric Acid → (trans)-3-Methyl-4-pyrrolidin-1-yl-piperidine dihydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][C@@H:11]([N:14]2[CH2:18][CH2:17][CH2:16][C:15]2=O)[C@H:10]([CH3:20])[CH2:9]1)=O)(C)(C)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].[ClH:27]>O1CCOCC1>[ClH:27].[ClH:27].[CH3:20][C@H:10]1[C@H:11]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH2:12][CH2:13][NH:8][CH2:9]1参加物
5
実験手順
The title compound was prepared in analogy to 193B, by reduction of (trans)-3-methyl-4-(2-oxo-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester with lithium aluminium hydride and subsequent deprotection with 4M hydrochloric acid in dioxane. MS: 169.2 (MH+).
出典と根拠
- ORDレコード
- ord-c00c0d66e8f641329edbd10c5d819fce
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07977358B2
反応ノート
読み込み中…